Which genetic condition is known to increase the likelihood of developing an aneurysm?

Marfan Syndrome is a genetic condition characterized by connective tissue abnormalities, which significantly increases the risk of various cardiovascular issues, including aneurysms. The disorder affects the body's ability to produce fibrillin-1, a protein critical for the strength and elasticity of connective tissues. As a result, individuals with Marfan Syndrome often experience dilation of the ascending aorta, leading to a higher likelihood of developing an aortic aneurysm. This condition requires ongoing monitoring and management, especially concerning cardiovascular health.

In contrast, the other conditions listed do not have the same association with aneurysm development. Turner Syndrome primarily affects females and is linked to various physical features and health issues, but does not have a strong connection to aneurysms. Cystic Fibrosis mainly affects the respiratory and digestive systems due to mucus buildup, while Klinefelter Syndrome is characterized by an extra X chromosome in males, influencing hormonal levels and fertility but not directly increasing aneurysm risk. These differences highlight the unique predisposition to aneurysms specifically associated with Marfan Syndrome.